NINDS PSPP staff report test results to participants and provide advice on next steps for promising agents. Under NINDS direction, preclinical testing of submitted agents is performed by contract facilities on a blinded and confidential basis and at no cost to the PSPP participants. With NIH HEAL (Helping to End Addiction Long-term) Initiative support, NINDS is developing a Preclinical Screening Platform for Pain (PSPP) program to facilitate the identification of potential non-addictive treatments (small molecules, biologics, devices, or natural products) for acute and chronic pain conditions.
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